September 20, 2020

When Testosterone Doesn’t Lead to Better Erections

The use of anabolic steroids usually leads to heightened sexual desire and increased frequency and quality of erections whether they are used for medical or non-medical (bodybuilding) purposes. Nelson Vergel, author of “Testosterone: A Man’s Guide“, discusses the effects of testosterone replacement therapy (TRT) on libido but more importantly discusses what happens when TRT doesn’t improve libido and lead to improved erectile functioning. He discusses the use of phosphodiesterase type 5 inhibitor (PD-5) drugs like Viagra, Cialis, and Levitra that can be used in conjunction with testosterone replacement therapy. [Read more…]

Blood Booster EPO Only the Tip of the Iceberg in Cycling

Widespread doping continues in cycling despite recent proclamations by Olivier Rabin, the science director for World Anti-Doping Agency (WADA), and Pierre Bordry, the head of the French Anti-Doping Agency (AFLD), that they are practically on the verge of eliminating doping from cycling.

The testosterone doping test is flawed. The EPO test is flawed in more ways than one. Peptide hormones such as human growth hormone (HGH) and insulin-like growth factor (IGF-1) are currently undetectable. And this does not begin to address other current and emerging synthetic blood boosting techniques being used by cyclists.

It seems that anti-doping agencies are happy to assert that they are winning the war on doping while neglecting issues such as biogeneric/biosimilar erythropoietin (EPO) stimulating proteins (ESPs); blood oxygen carriers: perfluorocarbon emulsions (PFCEs) and hemoglobin based oxygen carriers (HBOCs); hydroxyethylstarch (HES/HAES); and before long, if not already, EPO-mimetic peptide (EMPs). [Read more…]

Teen Extracurricular Steroid Chemistry and Marketing Experiment

Matthew Wong is not your average 17-year old high school student. He is an innovative entrepreneur, lacking in his legal education, who used the internet to order raw steroid powder from China to manufacture and distribute anabolic steroids in extracurricular chemistry and marketing experiments. Unlike his high school classmates, Wong has been in jail for the past two weeks socializing with Tarrant County criminals (“Steroid labs in Tarrant area are processing powder bought online,” April 23).

The arrests came after a two-month investigation prompted by a tip, Grapevine police Lt. Todd Dearing said. Matthew Wong, 17, of Grapevine was arrested April 10 on suspicion of possession of controlled substances and dangerous drugs and on suspicion of delivery of controlled substances. The charges range from state jail felonies to second-degree felonies, Dearing said. Wong remained in the Tarrant County Jail on Tuesday with bail set at $26,000.

Police say Wong sold an undercover officer steroids numerous times. According to an arrest warrant affidavit, Wong most recently met the undercover officer on Feb. 21 in a restaurant parking lot, where the officer bought 21.8 grams of Oxymetholone, a strong steroid, and 19.6 grams of testosterone from Wong for $310.

Steroid Testing Kit for Home Use

Confirm Biosciences has released a new home anabolic steroid testing kit this month. CNBC’s Sports Biz with Darren Rovell thinks it would be useful for parents to test their children for steroid use. Athletes may found it useful and convenient to monitor the elimination of banned substances from their bodies.

STEROIDCONFIRM™ enables sports trainers, employers and parents to test individuals who they suspect may be abusing steroids. Simply take a urine specimen at home, in the workplace or at school, and mail to our laboratory using the pre-paid shipping pak. You have the option to perform a confidential test (no personal information is required) or a test with a Chain of Custody…

Using Liquid Chromatograph Tandem Mass Spectrometry (LC/MS/MS), the most sophisticated and sensitive technology available for the steroid testing community, STEROIDCONFIRM™ can accurately quantify substances well below the cut-off levels. Each specimen is tested directly with this instrument – there is no screening process.

Confirm Biosciences claims the SteroidConfirm steroid testing kit is comparable to the steroid panels used by the World Anti-Doping Agency (WADA). This may be misleading. [Read more…]

"Stupidity and Mistakes of the Anti-Doping Crusade"

Velo Vortmax blasts WADA for its resistance to change in the face of additional new evidence that the testosterone:epitestosterone ratio test is flawed (“Genetic variations in enzyme UGT2B17: Implications,” April 3).

WADA refuses to worry about trivial genetic factors. WADA is loath to do longitudinal tests of athletes. WADA might find a variable that might refute their laboratory findings or challenge their presumption of laboratory perfection. WADA would never invest time and money doing pedigree studies to determine if a single metabolite above threshold for exogenous testosterone is a trait common in a family, or among a group of people found in a geographical region. But idiosyncratic individual differences in medicine have been documented in many pedigree studies. For example, hematocrit levels above 50% have been found in fathers and sons of elite cyclists. These hematocirt levels are inherited tendencies, not based on EPO doping. The same is true for testosterone/epitestosterone ratio(s) and may be true for Carbon Isotope metabolite delta/delta scores.

[Read more…]

Testosterone:Epitestosterone Ratio Test – False Negatives and False Positives

Source: Wikipedia

The scientific and anti-doping community continue to struggle with the development a test for exogenous growth hormone in athletes. They haven’t even been able to produce scientific evidence that growth hormone enhances athletic performance in spite of anecdotal evidence [from athletes and strength coaches] that this is the case.

But science continues to do a good job at finding weakness in the doping controls currently in place. Tip of the hat to Trust But Verify for alerting us of a new study which, among other things, tells us exactly how much exogenous testosterone some athletes can use and still pass the drug test.

The study reveals serious weaknesses in the testosterone:epitestosterone ratio test used by WADA and other anti-doping organizations (“Doping Test in Sports Confounded by Common Genetic Trait,” March 21). [Read more…]

Floyd Landis and Court of Arbitration for Sport

The Floyd Landis hearing before the Court of Arbitration for Sport (CAS) began today in Manhattan; for an excellent overview as usual see TBV. The five day appeal hearing is the last remedy in the appeal process for Floyd’s doping case involving positive testosterone test (“Landis, Stripped of Tour Title, Begins Final Appeal,” March 19).

Landis, 32, has spent millions of dollars on a defense that tried to cast doubt on the scientific validity of doping tests and the procedures followed at antidoping labs. But last September, in a 2-to-1 ruling, a United States Anti-Doping Agency arbitration panel concluded that Landis had used synthetic testosterone to achieve his comeback win at the 2006 Tour. As a result, he was barred from racing until January 2009….

In its 84-page ruling last year, the United States Anti-Doping Agency panel accepted Landis’s argument that the French antidoping lab that tested his urine samples from the Tour was sloppy in some of its operating procedures, and in how it documented its work. But the panel also found that a more sophisticated second test, conducted after the initial screening proved positive, was accurate.

But make no mistake about it, this isn’t just about Floyd Landis. It is also about the World Anti-Doping Agency (WADA), the anti-doping organization and program that is held as the model for drug testing around the world.

Football Player Sues Supplement Company for Undeclared Steroidal Ingredient

No sooner than I finished writing an article critical of the supplement industry does a professional football player file a lawsuit against a supplement company for containing steroids in their supplements (due to either contamination or intentional “spiking” of the ingredients). It gives me no pleasure to write this story because the defendant is a friend of mine.

Former NFL running back Femi Ayanbadejo has filed a lawsuit against Author L. Rea of ALR Industries. He claims an undisclosed ingredient in ALRI Max LMG caused him to fail an NFL doping test leading to his release by the Arizona Cardinals and Chicago Bears. Ayanbadejo tested positive for a “form of nandrolone.” Ayanbadejo’s attorney is blaming the positive steroid test on the manufacturer for possibly intentionally “spiking” the supplement with banned substances or contamination from the manufacturing facility.

I have not had a chance to review legal documents in the case. The owner of ALR Industries did not seem to be aware of the lawsuit and could not provide me with any insight into the case.

But on the surface, I’m not sure it has merit from a legal standpoint. [Read more…]

Synergistic Effects of Growth Hormone with Performance Enhancing Drugs

Dr. Gary Gaffney from Steroid Nation posted an article on Huffington Post about the performance enhancing effects of human growth hormone. Gaffney responds to so-called experts who assert with certainty that growth hormone does not help performance in sports. As Lou Schuler stated in a recent post, the true effects of growth hormone on performance are not always empirically “knowable and measurable.”

Gaffney takes note of the lack of empirical research examining the performance enhancing effects of drugs that has historically resulted in mainstream medical organizations failing to recognize performance enhancing drugs. Given this along with results seen in “experiments of nature,” Gaffney feels it is reasonable to conclude that GH has performance enhancing effects:

[Read more…]

Difference Between Growth Hormone and Testosterone

Many people seem to assume that growth hormone and testosterone are both anabolic steroids. The media has shown very little interest in distinguishing the two throughout the entire war of steroids or the steroids in baseball fiasco. (Never mind the fact that there are dozens of different steroids with differing effects and side effects within the class of anabolic steroids.) When Sylvester Stallone tried to explain that growth hormone was a completely different class of drugs than anabolic steroids, he was met with widespread disbelief if not ridicule. Never mind the fact that he was correct.

So, I have to give credit to the few journalists who “try” to explain the difference between growth hormone and anabolic steroids like testosterone e.g. The Growth Hormone Myth: [Read more…]